Recent published research [1,2] has confirmed the downregulation of NF-kappaB signaling pathway by Magnolol. This property of Magnolol can, in the case of topical application, help fight against age-related chronic micro-inflammation. This activity, combined with the well known antioxidant properties of Magnolol, indicate a strong protective potential for Magnolol, especially in anti-aging skin care applications. CARE ACTIV Ingredients offers CARE ACTIV MAGNOLOL, which is a natural and pure Magnolol, to formulate skin care applications with a well defined Magnolol composition.
1. Magnolol protects neurons against ischemia injury via the downregulation of p38/MAPK, CHOP and nitrotyrosine. Chen JH, Kuo HC, Lee KF, Tsai TH. Toxicol Appl Pharmacol. 2014 Jul 16. [Epub ahead of print]
2. Magnolol Inhibits Tumor Necrosis Factor-α-Induced ICAM-1 Expression via Suppressing NF-κB And MAPK Signaling Pathways in Human Lung Epithelial Cells. Chunlian W, Heyong W, Jia X, Jie H, Xi C, Gentao L. Inflammation. 2014 Jun 4. [Epub ahead of print]